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GI Effects / Comprehensive Stool Analysis
Assessment Scope: Advanced DNA & Biomarker Stool Analysis
Objective: Decoding gastrointestinal pathophysiology across microbiome, digestion, inflammation, and infection vectors to guide precision microbiome therapies.
I. Rationale for the GI Effects Assessment
Clinical Core: The gut is not merely a digestive organ; it houses over 70% of the body's immune cells and regulates neurotransmission and systemic inflammation via the Gut-Brain Axis. Root causes of systemic sub-health issues (such as chronic inflammation, eczema/allergies, brain fog, intractable bloating, diarrhea, or constipation) frequently stem from mucosal barrier breakdown, exocrine pancreatic insufficiency, or structural microbiome collapses. While conventional colonoscopy identifies gross anatomical lesions (e.g., polyps, malignancies), this
advanced biomarker assessment looks directly into "cellular and microecological functionality" — evaluating real-time inflammation, digestive capacities, and microbial dynamics.
1. Formulate "Strain-Specific" Personalized Probiotics:
Probiotic replenishment must be targeted based on actual deficiencies. Utilizing high-precision PCR DNA technology to quantify core commensal phyla and genera, this test identifies exactly which protective strains are lacking, allowing for professional customized blending rather than blind generic supplementation.
2. Assess Digestive & Absorptive Efficiency for Nutrient Tailoring:
Nutritional intake does not equate to cellular absorption. By measuring pancreatic enzyme secretions and fecal fat/protein remnants, we determine if sub-clinical pancreatic insufficiency or low bile acid output is causing nutrient malabsorption, directing whether specific digestive enzymes or betaine HCl must be included in your daily custom regimen.
3. Detect Hidden Intestinal Inflammation and Leaky Gut Risks:
Chronic luminal inflammation degrades tight junction proteins, causing intestinal permeability (Leaky Gut). This allows undigested food macromolecules and endotoxins to translocate into systemic circulation, triggering systemic autoimmunity and brain fog. Inflammatory biomarkers help intercept this pathology early.
II. Comprehensively Measured Biomarkers
GI Effects
1. Digestion & Absorption Markers
Pancreatic Elastase-1: The gold-standard biomarker for exocrine pancreatic function. Low levels indicate pancreatic insufficiency, leading to bloating and macro-nutrient malabsorption.
Fecal Fats & Putrefactive Products: Quantifies long-chain fatty acids and total fecal fats to evaluate lipid emulsification (e.g., bile insufficiency) and protein putrefaction status.
2. Inflammation & Intestinal Immune Barrier Markers Calprotectin: A critical neutrophilic marker used clinically to differentiate between IBS and IBD. Highly elevated levels signal active mucosal inflammatory damage.
Eosinophil Protein X (EPX): Evaluates allergic or hypersensitivity immune responses triggered by dietary allergens or parasitic pathogens within the gut lumen.
Secretory IgA (sIgA): The frontline antibody shielding the gut mucosal lining. Deficient sIgA indicates mucosal immune exhaustion, elevating leaky gut and systemic toxic translocation risks.
3. Metabolic & Short-Chain Fatty Acids (SCFAs) Markers Total SCFAs: Critical therapeutic metabolites generated via the fermentation of prebiotic dietary fibers by beneficial commensals.
Butyrate: The primary fuel source for colonocytes. It exercises potent anti-nflammatory effects, maintains epithelial tight junctions, and plays a vital role in colorectal oncological prevention.
β-Glucuronidase: Measures whether hepatic Phase II detoxified compounds (e.g., estrogens, xenobiotics) are being pathologically reactivated and reabsorbed due to specific bacterial dysbiosi
4. Commensal Microbiome Profiling via High-Throughput PCR Microbial Diversity & Equitability: Applies target 24-S rRNA gene amplification to map theproportional density of key bacterial phyla (Firmicutes, Bacteroidetes, Proteobacteria, etc.), plotting overall dysbiosis patterns.
Keystone Protective Species: Quantifies absolute genomic counts of keystone beneficial organisms, including Bifidobacterium, Lactobacillus, and Akkermansia muciniphila (critical for mucin layer integrity).
5. Enteric Pathogens & Parasitology Screening
Pathogenic Bacteria, Yeast, & Parasites: Rules out acute/chronic infectious enteritis driven by Clostridioides difficile, Salmonella, protozoan parasites, or opportunistic fungal overgrowth (e.g., Candida albicans) that trigger intractable GI symptoms.
III. Directed Precision Custom Interventions
*** If our standard options do not fully meet your needs, please contact us for a fully customized testing consultation tailored to your goals.
腸道菌相與消化功能綜合分析 · 臨床科學深度評估報告
III. Deliverables of Your Tailored Protocol
檢測範疇 : 高級DNA與生化指標糞便分析
臨床宗旨 : 由微生態、消化、發炎、感染四大維度,精準破譯腸道病理生理學狀態,指導個人化益生菌配方與消化重塑治療
一、 為什麼要做這項檢測?
臨床核心:腸道不僅是消化器官,更是人體70%以上的免疫細胞聚集地,並透過「菌腦軸(Gut-Brain Axis)」 深度調控大腦情緒與全身免疫發炎。許多長期的亞健康症狀(如慢性發炎、皮膚過敏、腦霧、無法根治的胃腸 脹氣、腹瀉或便秘),其根本原因皆源於腸道黏膜破損、腺體消化酵素不足或特定菌相結構崩解。常規的大腸 鏡只能檢查大體結構病變(如瘜肉、腫瘤),而本檢測則是從「細胞與微生態功能」層面,全面看透腸道內部 的微生態平衡、發炎程度與消化效能。
1. 精準客製「菌株特異性」益生菌:
益生菌的補充必須「補其所需,對症下藥」。本檢測利用高精準度 PCR DNA 技術量化腸道內各核心菌屬群 落,能精確揭示哪些關鍵核心菌群(如雙歧桿菌、乳酸桿菌)嚴重匱乏,從而進行精準高階定製,避免盲目補 充無效菌株。
2. 評估消化吸收效率,指導營養素定製:
吃進去的營養不等於吸收到的營養。檢測胰臟酵素分泌指標與糞便脂肪、蛋白質殘留量,能評估你是否因胃酸 不足、膽汁分泌受阻或胰臟功能疲弱導致「吃好卻不吸收」,藉此指導每日核心補充劑中是否需要加入特定消 化酵素或胃酸因子。
3. 偵測隱性腸道發炎與腸漏症風險:
腸道慢性發炎會破壞緊密連接蛋白,導致腸漏(Gut Leaking),使未消化完全的食物大分子與毒素直接滲透入 血液,誘發全身性自體免疫疾病與腦霧。透過發炎生物標記,能提早攔截病變。
二、 這項檢測具體能測到什麼?
綜合分析涵蓋了四大核心醫學維度,提供高度精確的生化與基因數據對照:
1. 消化與吸收指標
胰臟彈性蛋白酶 : 評估胰臟 外分泌腺功能最穩定的指標。若數值低下,代表消化 酵素嚴重不足,直接引發脹氣、營養吸收不良。
脂肪與蛋白質殘留 : 檢測糞便中長鏈脂肪酸與總脂肪含量,評 估脂肪脂肪消化率(如膽汁酸缺 乏)與蛋白質分解是 否完全。
2. 腸道發炎與免疫屏障指標
鈣衛蛋白 : 臨床區分腸躁症(IBS)與 發炎性腸道疾病(IBD)的關鍵嗜中性球白血球指 標。數值偏高代表大腸黏膜正面臨實質發炎破壞。
嗜酸性球蛋白 : 評估腸道對食物過敏原或寄生蟲 引發的特異性過敏與免疫發炎反應。
分泌型 : 腸道黏膜表面的第一線 免疫抗體防禦網。過低代表腸道黏膜免疫力衰竭,極易造成腸肉毒素滲透
3. 代謝與短鏈脂肪酸指標
總短鏈脂肪酸 : 益生菌發酵膳食纖維產 生的關鍵代謝物。
丁酸 / 酪酸 : 結腸上皮細胞最核心的能量來 源。具備強大的抗發炎、修復腸道黏膜緊密連接、以 及預防大腸癌病變的臨床核心功能。
β-葡萄糖苷酸酶 : 反映肝臟第二階 段雌激素與環境毒素排毒路徑是否遭腸道壞菌逆向解 離(即解毒後的毒素在腸道被重新吸收)。
4. 共生菌群相平衡
菌相多元性與平衡度 : 利用 24-S rRNA 高階基因技術,量化體內五大核心菌門 (厚壁菌門、擬桿菌門、變形菌門等)的相對比例, 評估是否有整體性生態失衡。
關鍵核心保護菌 : 精準計 數雙歧桿菌、乳酸桿菌 以及嗜粘蛋白阿克曼氏菌 菌)等關鍵黏膜保護菌的絕對基底總量。
5. 病原微生物與寄生蟲篩檢
細菌、黴菌與寄生蟲篩檢: 排除急慢性致病菌(如艱 難梭菌、沙門氏菌)、寄生蟲(如阿米巴原蟲)與念 珠菌 等條件致病性真菌的隱性感染,這 往往是頑固性消化腹瀉的隱形元凶。
三、 基於報告的個人化精準配方方向
本報告將直接轉化為以下「科學個人化定製」黃金三角方案:
【定製特異性活性益生菌】 根據第四項菌群缺失數據,不盲用通配菌株。若 AKK 菌不足則強化膳食多酚,若 雙歧桿菌過低則定製高純度特定雙歧菌株組合,精準靶向定殖。
【個人化每日消化支持與黏膜修復包】 根據第一、二項指標。若胰臟酶低下則於每日餐包中配備高活性植物/ 動物複合消化酵素;若分泌型 IgA 過低或面臨腸漏風險,則配方中精準增添麩醯胺酸(L-Glutamine)、初乳 蛋白與鋅肌肽進行黏膜屏障實質修復。
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