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Food Sensitivity / Allergy Testing (IgE & IgG / IgG4 Analysis)
Assessment Scope: Serum-Specific Antibody Quantitative Immunoassay
Objective: (IgG/IgG4) Integrating acute allergy [IgE] and delayed inflammation/sensitivity [IgG/IgG4] immune networks to map physiological reactions to specific foods, directing precision elimination diets and mucosal healing.
I. Rationale for Food Allergy & Sensitivity Testing
Clinical Core: Dietary items can trigger two fundamentally distinct neuro-immunological pathways within the body: **acute allergies** and **delayed systemic sensitivities**. Many individuals battle intractable eczema, idiopathic urticaria, persistent bloating, migratory arthralgia, or recurrent migraines and brain fog, failing standard clinical diagnostic pathways. This is because conventional diagnostics look solely at immediate IgE-mediated reactions manifesting within minutes. Conversely, delayed sensitivities mediated by IgG and IgG4 complexes take 24 to 72 hours to unfold. Blindly ingesting these reactive foods forms circulating immune complexes that deposit systemically, driving low-grade chronic inflammation and degrading the gut lining (leaky gut). This comprehensive test maps both immediate and delayed pathways to pinpoint hidden immunological triggers.
1. Differentiate Immediate Hypersensitivity from Delayed Immune Loading:
Acute allergy (IgE) is acute and potentially life-threatening via severe histamine release. Delayed sensitivity (IgG) is insidious; due to mucosal hyper-permeability, undigested food macromolecules slip into blood circulation, prompting the immune system to deploy IgG antibodies. While metabolic tests flag leaky gut, this profile identifies the specific dietary fuels exacerbating the inflammatory fire.
2. Establish a Scientifically Structured Elimination and Rotation Protocol:
Blindly cutting out large food groups drives micro-nutrient malnutrition. By quantifying antibody tiers (Mild, Moderate, Severe), we map a systematic 3-to-6-month elimination program. Moderate reactivities are assigned a "4-day rotational diet," cooling down the immune overdrive and enabling mucosal recovery while preserving baseline metabolic stability.
3. Utilize IgG4 Co-Efficiency to Assess True Immunological Tolerance:
IgG4 serves as a physiological "brake" or regulatory molecule in mucosal immunology. If a food presents elevated IgG but exhibits high IgG4, it signifies that the body is actively building a tolerance framework, meaning strict restriction may be unwarranted. Joint IgG/IgG4 indexing offers a far more accurate, lower false-positive blueprint than isolated IgG testing.
II. What Exactly is Being Measured?
1. IgE-Mediated Immediate Hypersensitivity Markers
Type I Immediate Overdrive: Quantifies serum- specific IgE titers. It screens for items capable of inducing rapid mast-cell degranulation, angioedema,
pruritus, or anaphylaxis within minutes (e.g., severe immediate reactions to peanuts, shellfish, or tree nuts).
2. IgG-Mediated Delayed Sensitivity Profile
Type III Delayed Immune Complexing: Quantifies total food-specific IgG titers. When food antigens bypass a compromised gut barrier, they bind with IgG to form circulating immune complexes that deposit in cutaneous tissues (eczema), neurological systems (migraines/brain fog), or joints, generating systemic low-grade inflammation.
3. IgG4-Mediated Immunological Tolerance Subclass
Specific IgG4 Subclass Indexing: Measures food- specific IgG4 concentrations. IgG4 acts as a competitive antagonist against IgE and pro- inflammatory pathways, signaling mucosal desensitization and protecting against overly restrictive dietary deprivation.
4. Comprehensive Dietary Antigen Groupings
Dairy & Eggs: Cow's milk, Casein, Whey protein, Whole egg/Yolk.
Gluten & Grains: Wheat Gluten, Gliadin, Barley, Oats, Rice.
Nuts, Seeds & Legumes: Peanut, Soy, Cashew, Almond, Chickpea.
Proteins & Seafood: Chicken, Beef, Pork, Cod, Shrimp, Crab, Clam.
Fruits & Vegetables: Kiwi, Strawberry, Citrus, Tomato, Spinach, Fungi.
Spices & Stimulants: Coffee, Cocoa, Bakers/ Brewers Yeast, Mustard.
III. Data-Driven Dietary Reconstructive Strategy
*** If our standard options do not fully meet your needs, please contact us for a fully customized testing consultation tailored to your goals.
食物過敏與慢性不耐受綜合分析 · 臨床全身性免疫與發炎屏障評估報告
檢測範疇: 血清特異性抗體定量免疫分析
臨床宗旨: 結合急性過敏(IgE)與慢性發炎/不耐受(IgG/IgG4)免疫複合物網絡,全面定位身體對特定食物品項 的局部及全身性免疫反應,精確指導飲食排除療法、系統解毒與黏膜屏障修復。
一、 為什麼要做這項檢測?
臨床核心:食物在體內可能引發兩種完全不同的免疫發炎反應:**「急性過敏」**與**「慢性不耐受」**。許多
人長期深受皮膚蕁麻疹、濕疹、反覆脹氣、關節發炎或不明原因的「偏頭痛與腦霧」 所苦,看遍各科都查不出
原因。這是因為傳統檢查往往只針對吃完幾分鐘內發作的 IgE 急性過敏;然而,由 IgG/IgG4 介導的慢性敏
感,其發作可延遲至 24 到 72 小時之後。如果盲目攝入身體不耐受的食物,免疫複合物會隨血液流經全身,導
致系統性慢性發炎並破壞小腸黏膜(引發腸漏症)。本檢測旨在一次看清急性與慢性過敏全貌,找出破壞免疫
平衡的「隱形地雷」。
1. 釐清急性發作與慢性延遲反應的本質區別:
急性過敏(IgE)是致命或劇烈的,會釋放大量組織胺;而慢性過敏(IgG)是隱匿的,它是因為腸道黏膜屏障
破損,食物大分子滲入血液,誘發免疫系統產生 IgG 抗體進行包圍。OAT 與菌相檢測往往指出腸道屏障受損,
而本檢測能直接抓出是哪些特定食物正在「火上澆油」。
2. 建立精準「飲食排除法」與「低發炎輪替餐」:
「盲目斷食」或「全面禁食」會導致嚴重的隱性營養飢餓。透過量化數據(輕度、中度、重度不耐受),可以 規劃科學的 3 至 6 個月排除飲食計畫,並針對中度敏感食物規劃「4天輪替飲食法」,既能有效讓免疫系統降 溫、修復腸道,又能維持基礎代謝所需的微量元素平衡。
3. 引入 IgG4 阻斷抗體指標,評估真實免疫耐受度:
IgG4 在免疫學中扮演「調節與煞車」的角色。如果某種食物的 IgG 很高,但伴隨著足夠的 IgG4,代表身體正 在主動建立對它的耐受性,不一定需要被嚴格禁食。結合 IgG 與 IgG4 的聯合分析,能提供比單純 IgG 檢測更 少「假陽性」、更精確的個人化調理藍圖。
二、 這項檢測具體能測到什麼?
該項目通常篩檢 90 到 220 多項常見的亞洲與全球跨區域飲食抗原,具體將免疫指標分為三大維度對照:
1. 急性過敏免疫球蛋白 (IgE-Mediated Acute Allergens)
I型速發型過敏反應: 檢測血清中特異性 IgE 濃度。針 對一吃進去便可能引發皮膚紅腫、喉嚨發癢、呼吸急 促甚至休克(如部分人群對花生、海鮮、堅果)的品 項進行絕對量化。
2. 慢性發炎與延遲性不耐受 (IgG-Mediated Delayed Sensitivity)
III型遲發型過敏反應: 檢測食物特異性 IgG 總量。當食 物大分子透過受損腸壁進入血液時,會與 IgG 結合形 成免疫複合物,沉積在皮膚(濕疹)、神經(偏頭痛/ 腦霧)或肌肉關節中,造成長期低度發炎。
3. 免疫調節阻斷抗體 (IgG4-Mediated Tolerance Subclass)
IgG4 特異性亞型分析: 測量食物特異性 IgG4 水平。 IgG4 能與 IgE 和 IgG 競爭結合位點,起到「緩衝與 保護」作用,幫助醫生客觀評估黏膜的真實免疫耐受 力,防止過度限制飲食。
4. 跨品項飲食抗原大分類 (Comprehensive Dietary Antigen Panels)
乳製品與蛋類: 牛奶、酪蛋白、乳清蛋白、蛋白/蛋黃。
麩質與穀物: 小麥麩質(Gluten)、大麥、燕麥、米。
堅果與豆類: 花生、大豆、腰果、杏仁、黃豆、鷹嘴 豆。
肉類與海鮮: 雞肉、牛肉、豬肉、鱈魚、蝦、蟹、蛤 蜊。
水果與蔬菜: 奇異果、草莓、柑橘、番茄、菠菜、菌 菇。
香料與調味品: 咖啡、可可、酵母(Yeast)、芥末、 香草。
三、 科學定製的飲食重塑方案
這份檢測的終極臨床產出並非只是叫您「什麼都不能吃」,而是精確指導個人化健康補充劑與日常飲食包的定製:
【個人化每日低敏防禦餐包】 徹底剔除重度 IgG 且無 IgG4 保護的核心品項(常見如麩質或酪蛋白),將安全
的、無發炎反應的替代碳水與微量元素精確定量打包至您的每日定製餐包中。
【靶向性小腸黏膜漏修復方】 凡是出現大面積、多品項高度慢性敏感者,皆暗示存在嚴重的「腸漏症」。每
日調理包中必須精準加強 **L-麩醯胺酸 (L-Glutamine)、鋅肌肽 (Zinc Carnosine) 與高濃度初乳免疫球蛋白
**,在禁絕地雷食物的同時,快速閉合上皮細胞間隙,徹底逆轉食物不耐受。
***若上述項目未能完全符合您的需求，歡迎聯絡我們，我們將為您安排專屬的客製化檢測諮詢。